Synthesis and Anti-Proliferative Effects of Mono- and Bis-Purinomimetics Targeting Kinases

A series of mono-pyrrolo[2,3-d]pyrimidines 4a–4k, unsymmetrical bis-purine isosteres 5a–5e and symmetrical bis-pyrrolo[2,3-d]pyrimidines 6a and 6b connected via di(1,2,3-triazolyl)phenyl linker were synthesized by click chemistry. Whereas mono- 4g and bis-pseudopurine 5e showed selective inhibitory...

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Publicado en:Int J Mol Sci
Main Authors: Bistrović, Andrea, Harej, Anja, Grbčić, Petra, Sedić, Mirela, Kraljević Pavelić, Sandra, Cetina, Mario, Raić-Malić, Silvana
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5713262/
https://ncbi.nlm.nih.gov/pubmed/29104242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18112292
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