Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure

[Image: see text] Therapeutic options for brain infections caused by pathogens with a reduced sensitivity to drugs are limited. Recent reports on the potential use of linezolid in treating brain infections prompted us to design novel compounds around this scaffold. Herein, we describe the design and...

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Publicado en:ACS Med Chem Lett
Autores principales: Seetharamsingh, B., Ramesh, Remya, Dange, Santoshkumar S., Khairnar, Pankaj V., Singhal, Smita, Upadhyay, Dilip, Veeraraghavan, Sridhar, Viswanadha, Srikant, Vakkalanka, Swaroop, Reddy, D. Srinivasa
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2015
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645245/
https://ncbi.nlm.nih.gov/pubmed/26617962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00213
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