Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure

[Image: see text] Therapeutic options for brain infections caused by pathogens with a reduced sensitivity to drugs are limited. Recent reports on the potential use of linezolid in treating brain infections prompted us to design novel compounds around this scaffold. Herein, we describe the design and...

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Bibliografiset tiedot
Julkaisussa:ACS Med Chem Lett
Päätekijät: Seetharamsingh, B., Ramesh, Remya, Dange, Santoshkumar S., Khairnar, Pankaj V., Singhal, Smita, Upadhyay, Dilip, Veeraraghavan, Sridhar, Viswanadha, Srikant, Vakkalanka, Swaroop, Reddy, D. Srinivasa
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2015
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645245/
https://ncbi.nlm.nih.gov/pubmed/26617962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00213
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