The effects of ibudilast, a glial activation inhibitor, on opioid withdrawal symptoms in opioid-dependent volunteers

Glial activation is hypothesized to contribute directly to opioid withdrawal. This study investigated the dose-dependent effects of a glial cell-modulator, ibudilast, on withdrawal symptoms in opioid-dependent volunteers after abrupt discontinuation of morphine administration. METHODS: Non-treatment...

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Veröffentlicht in:Addict Biol
Hauptverfasser: Cooper, ZD, Johnson, KW, Pavlicova, M, Glass, A, Vosburg, SK, Sullivan, MA, Manubay, J, Martinez, D, Jones, JD, Saccone, PA, Comer, SD
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4644513/
https://ncbi.nlm.nih.gov/pubmed/25975386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/adb.12261
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