Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast)

Morphine-induced glial proinflammatory responses have been documented to contribute to tolerance to opioid analgesia. Here, we examined whether drugs previously shown to suppress glial proinflammatory responses can alter other clinically relevant opioid effects; namely, withdrawal or acute analgesia...

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Detaylı Bibliyografya
Asıl Yazarlar: Hutchinson, Mark R., Lewis, Susannah S., Coats, Benjamen D., Skyba, David A., Crysdale, Nicole Y., Berkelhammer, Debra L., Brzeski, Anita, Northcutt, Alexis, Vietz, Christine M., Judd, Charles M., Maier, Steven F., Watkins, Linda R., Johnson, Kirk W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2008
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662518/
https://ncbi.nlm.nih.gov/pubmed/18938237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2008.09.012
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