Kinome-wide Decoding of Network-Attacking Mutations Rewiring Cancer Signaling

Cancer cells acquire pathological phenotypes through accumulation of mutations that perturb signaling networks. However, global analysis of these events is currently limited. Here, we identify six types of network-attacking mutations (NAMs), including changes in kinase and SH2 modulation, network re...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell
Prif Awduron: Creixell, Pau, Schoof, Erwin M., Simpson, Craig D., Longden, James, Miller, Chad J., Lou, Hua Jane, Perryman, Lara, Cox, Thomas R., Zivanovic, Nevena, Palmeri, Antonio, Wesolowska-Andersen, Agata, Helmer-Citterich, Manuela, Ferkinghoff-Borg, Jesper, Itamochi, Hiroaki, Bodenmiller, Bernd, Erler, Janine T., Turk, Benjamin E., Linding, Rune
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cell Press 2015
Pynciau:
Resource
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4644236/
https://ncbi.nlm.nih.gov/pubmed/26388441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.08.056
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