Kinome-wide Decoding of Network-Attacking Mutations Rewiring Cancer Signaling

Cancer cells acquire pathological phenotypes through accumulation of mutations that perturb signaling networks. However, global analysis of these events is currently limited. Here, we identify six types of network-attacking mutations (NAMs), including changes in kinase and SH2 modulation, network re...

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Publicado no:Cell
Main Authors: Creixell, Pau, Schoof, Erwin M., Simpson, Craig D., Longden, James, Miller, Chad J., Lou, Hua Jane, Perryman, Lara, Cox, Thomas R., Zivanovic, Nevena, Palmeri, Antonio, Wesolowska-Andersen, Agata, Helmer-Citterich, Manuela, Ferkinghoff-Borg, Jesper, Itamochi, Hiroaki, Bodenmiller, Bernd, Erler, Janine T., Turk, Benjamin E., Linding, Rune
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4644236/
https://ncbi.nlm.nih.gov/pubmed/26388441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.08.056
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