HMGB1 Promotes Mitochondrial Dysfunction–Triggered Striatal Neurodegeneration via Autophagy and Apoptosis Activation

Impairments in mitochondrial energy metabolism are thought to be involved in many neurodegenerative diseases. The mitochondrial inhibitor 3-nitropropionic acid (3-NP) induces striatal pathology mimicking neurodegeneration in vivo. Previous studies showed that 3-NP also triggered autophagy activation...

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Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Qi, Lin, Sun, Xue, Li, Feng-E, Zhu, Bao-Song, Braun, Frank K., Liu, Zhi-Qiang, Tang, Jin-Le, Wu, Chao, Xu, Fei, Wang, Hui-Han, Velasquez, Luis A., Zhao, Kui, Lei, Feng-Rui, Zhang, Ji-Gang, Shen, Yun-Tian, Zou, Jian-Xuan, Meng, Hui-Min, An, Gang-Li, Yang, Lin, Zhang, Xing-Ding
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2015
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643922/
https://ncbi.nlm.nih.gov/pubmed/26565401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142901
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