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Severe Neurodegeneration with Impaired Autophagy Mechanism Triggered by Ostm1 Deficiency
Loss of Ostm1 leads to the most severe form of osteopetrosis in mice and humans. Because functional rescue of the osteopetrotic defect in these mice extended their lifespan from ∼3 weeks to 6 weeks, this unraveled a second essential role of Ostm1. We discovered that Ostm1 is highly expressed in the...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4022863/ https://ncbi.nlm.nih.gov/pubmed/24719316 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.537233 |
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