Small-molecule inhibitors of ERK-mediated immediate early gene expression and proliferation of melanoma cells expressing mutated BRaf

Constitutive activation of the extracellular-signal-regulated kinases 1 and 2 (ERK1/2) are central to regulating the proliferation and survival of many cancer cells. The current inhibitors of ERK1/2 target ATP binding or the catalytic site and are therefore limited in their utility for elucidating t...

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Detalhes bibliográficos
Publicado no:Biochem J
Main Authors: Samadani, Ramin, Zhang, Jun, Brophy, Amanda, Oashi, Taiji, Priyakumar, U. Deva, Raman, E. Prabhu, St John, Franz J., Jung, Kwan-Young, Fletcher, Steven, Pozharski, Edwin, MacKerell, Alexander D., Shapiro, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643458/
https://ncbi.nlm.nih.gov/pubmed/25695333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20131571
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