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Combined deficiency of Notch1 and Notch3 causes pericyte dysfunction, models CADASIL, and results in arteriovenous malformations
Pericytes regulate vessel stability and pericyte dysfunction contributes to retinopathies, stroke, and cancer. Here we define Notch as a key regulator of pericyte function during angiogenesis. In Notch1(+/−); Notch3(−/−) mice, combined deficiency of Notch1 and Notch3 altered pericyte interaction wit...
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| 發表在: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4643246/ https://ncbi.nlm.nih.gov/pubmed/26563570 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16449 |
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