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Combined deficiency of Notch1 and Notch3 causes pericyte dysfunction, models CADASIL, and results in arteriovenous malformations

Pericytes regulate vessel stability and pericyte dysfunction contributes to retinopathies, stroke, and cancer. Here we define Notch as a key regulator of pericyte function during angiogenesis. In Notch1(+/−); Notch3(−/−) mice, combined deficiency of Notch1 and Notch3 altered pericyte interaction wit...

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Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Kofler, Natalie M., Cuervo, Henar, Uh, Minji K., Murtomäki, Aino, Kitajewski, Jan
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643246/
https://ncbi.nlm.nih.gov/pubmed/26563570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16449
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