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Next generation sequencing of stage IV squamous cell lung cancers reveals an association of PI3K aberrations and evidence of clonal heterogeneity in patients with brain metastases

Large-scale genomic characterization of squamous cell lung cancers (SQCLC) has revealed several putative oncogenic drivers. There are, however, little data to suggest that these alterations have clinical relevance. We performed comprehensive genomic profiling of 79 stage IV SQCLCs (including next-ge...

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Bibliografske podrobnosti
izdano v:Cancer Discov
Main Authors: Paik, Paul K., Shen, Ronglai, Won, Helen, Rekhtman, Natasha, Wang, Lu, Sima, Camelia S., Arora, Arshi, Seshan, Venkatraman, Ladanyi, Marc, Berger, Michael F., Kris, Mark G.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643059/
https://ncbi.nlm.nih.gov/pubmed/25929848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-1129
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