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Pancreatic Digestive Enzyme Blockade in the Intestine Increases Survival After Experimental Shock

Shock, sepsis, and multiorgan failure are associated with inflammation, morbidity, and high mortality. The underlying pathophysiological mechanism is unknown, but evidence suggests that pancreatic enzymes in the intestinal lumen autodigest the intestine and generate systemic inflammation. Blocking t...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: DeLano, Frank A., Hoyt, David B., Schmid-Schönbein, Geert W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643000/
https://ncbi.nlm.nih.gov/pubmed/23345609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3005046
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