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Structural insight on processivity, human disease and antiviral drug toxicity
DNA polymerase gamma (Pol γ) is a nuclear encoded, mitochondrially located replicase that conducts all DNA synthesis in the organelle. Structurally, human Pol γ closely resembles bacteriophage T7 DNA polymerase. Perhaps due to this prokaryotic-like feature, Pol γ is highly susceptible to inhibition...
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| I publikationen: | Curr Opin Struct Biol |
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| Huvudupphovsman: | |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2010
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4642886/ https://ncbi.nlm.nih.gov/pubmed/21185718 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sbi.2010.12.001 |
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