Low doses of ultraviolet radiation and oxidative damage induce dramatic accumulation of mitochondrial DNA replication intermediates, fork regression, and replication initiation shift

Mitochondrial DNA is prone to damage by various intrinsic as well as environmental stressors. DNA damage can in turn cause problems for replication, resulting in replication stalling and double-strand breaks, which are suspected to be the leading cause of pathological mtDNA rearrangements. In this s...

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Bibliographic Details
Published in:Mol Biol Cell
Main Authors: Torregrosa-Muñumer, Rubén, Goffart, Steffi, Haikonen, Juha A., Pohjoismäki, Jaakko L. O.
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2015
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4642854/
https://ncbi.nlm.nih.gov/pubmed/26399294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-06-0390
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