Peptide Splicing in the Proteasome Creates a Novel Type of Antigen with an Isopeptide Linkage

The proteasome is able to create spliced Ags, in which two distant parts of a protein are excised and ligated together to form a novel peptide, for presentation by MHC class I molecules. These noncontiguous epitopes are generated via a transpeptidation reaction catalyzed by the proteasomal active si...

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Détails bibliographiques
Publié dans:J Immunol
Auteurs principaux: Berkers, Celia R., de Jong, Annemieke, Schuurman, Karianne G., Linnemann, Carsten, Geenevasen, Jan A. J., Schumacher, Ton N. M., Rodenko, Boris, Ovaa, Huib
Format: Artigo
Langue:Inglês
Publié: AAI 2015
Sujets:
Antigen Recognition and Responses
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4642838/
https://ncbi.nlm.nih.gov/pubmed/26401000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402454
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