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Peptide Splicing in the Proteasome Creates a Novel Type of Antigen with an Isopeptide Linkage
The proteasome is able to create spliced Ags, in which two distant parts of a protein are excised and ligated together to form a novel peptide, for presentation by MHC class I molecules. These noncontiguous epitopes are generated via a transpeptidation reaction catalyzed by the proteasomal active si...
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| Pubblicato in: | J Immunol |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
AAI
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4642838/ https://ncbi.nlm.nih.gov/pubmed/26401000 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402454 |
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