In Vitro and In Vivo Sustained Zero-Order Delivery of Rapamycin (Sirolimus) From a Biodegradable Intraocular Device

PURPOSE: We created implantable intraocular devices capable of constant and continuous rapamycin release on the scale of months to years. METHODS: Polycaprolactone (PCL) thin films were used to encapsulate rapamycin to create implantable and biodegradable intraocular devices. Different film devices...

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Vydáno v:Invest Ophthalmol Vis Sci
Hlavní autoři: Lance, Kevin D., Good, Samuel D., Mendes, Thaís S., Ishikiriyama, Mynna, Chew, Patrick, Estes, Laurel S., Yamada, Kazuhito, Mudumba, Sri, Bhisitkul, Robert B., Desai, Tejal A.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Association for Research in Vision and Ophthalmology 2015
Témata:
Retina
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4642602/
https://ncbi.nlm.nih.gov/pubmed/26559479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-17757
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