Biocompatibility and Pharmacokinetic Analysis of an Intracameral Polycaprolactone Drug Delivery Implant for Glaucoma

PURPOSE: We developed polycaprolactone (PCL) implants that achieve zero-order release of a proprietary ocular hypotensive agent (DE-117) over 6 months. METHODS: The release rates of DE-117–loaded PCL devices were tuned based on an established predictive model and confirmed by in vitro release studie...

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Publicado en:Invest Ophthalmol Vis Sci
Autores principales: Kim, Jean, Kudisch, Max, Mudumba, Sri, Asada, Hiroyuki, Aya-Shibuya, Eri, Bhisitkul, Robert B., Desai, Tejal A.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Association for Research in Vision and Ophthalmology 2016
Materias:
Glaucoma
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5015984/
https://ncbi.nlm.nih.gov/pubmed/27556217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.16-19585
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