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Sirolimus (rapamycin) for the targeted treatment of the fibrotic sequelae of Graves’ orbitopathy
BACKGROUND: Rapamycin (alternatively known as sirolimus) is a macrolide immunosuppressant commonly used for organ transplantation. It acts both on lymphocytes through the mechanistic target of rapamycin (mTOR) pathway to reduce their sensitivity to interleukin-2 (IL-2) and, importantly, also has ant...
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| Published in: | Eye (Lond) |
|---|---|
| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group UK
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6461882/ https://ncbi.nlm.nih.gov/pubmed/30755726 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41433-019-0340-3 |
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