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Sirolimus (rapamycin) for the targeted treatment of the fibrotic sequelae of Graves’ orbitopathy

BACKGROUND: Rapamycin (alternatively known as sirolimus) is a macrolide immunosuppressant commonly used for organ transplantation. It acts both on lymphocytes through the mechanistic target of rapamycin (mTOR) pathway to reduce their sensitivity to interleukin-2 (IL-2) and, importantly, also has ant...

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Detalhes bibliográficos
Publicado no:Eye (Lond)
Main Authors: Roos, Jonathan C. P., Murthy, Rachna
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461882/
https://ncbi.nlm.nih.gov/pubmed/30755726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41433-019-0340-3
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