Ductal activation of oncogenic KRAS alone induces sarcomatoid phenotype

Salivary duct carcinoma (SDC) is an uncommon, but aggressive malignant tumor with a high mortality rate. Herein, we reported the detection of somatic KRAS A146T and Q61H mutations in 2 out of 4 (50%) sarcomatoid SDC variants. Transgenic mice carrying the human oncogenic KRAS(G12V), which spatiotempo...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Fu, Yong, Cruz-Monserrate, Zobeida, Helen Lin, H., Chung, Yiyin, Ji, Baoan, Lin, Szu-min, Vonderfecht, Steven, Logsdon, Craig D., Li, Chien-Feng, Ann, David K.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4642517/
https://ncbi.nlm.nih.gov/pubmed/26289340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep13347
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