NF2 loss promotes oncogenic RAS-induced thyroid cancers via YAP-dependent transactivation of RAS proteins and sensitizes them to MEK inhibition

Ch22q LOH is preferentially associated with RAS mutations in papillary and in poorly differentiated thyroid cancer (PDTC). The 22q tumor suppressor NF2, encoding merlin, is implicated in this interaction because of its frequent loss of function in human thyroid cancer cell lines. Nf2 deletion or Hra...

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Bibliografski detalji
Izdano u:Cancer Discov
Glavni autori: Garcia-Rendueles, Maria E.R., Ricarte-Filho, Julio C., Untch, Brian R., Landa, Iňigo, Knauf, Jeffrey A., Voza, Francesca, Smith, Vicki E., Ganly, Ian, Taylor, Barry S., Persaud, Yogindra, Oler, Gisele, Fang, Yuqiang, Jhanwar, Suresh C., Viale, Agnes, Heguy, Adriana, Huberman, Kety H., Giancotti, Filippo, Ghossein, Ronald, Fagin, James A.
Format: Artigo
Jezik:Inglês
Izdano: 2015
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4642441/
https://ncbi.nlm.nih.gov/pubmed/26359368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-0330
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