Knockout of Slo2.2 enhances itch, abolishes K(Na) current, and increases action potential firing frequency in DRG neurons

Two mammalian genes, Kcnt1 and Kcnt2, encode pore-forming subunits of Na(+)-dependent K(+) (K(Na)) channels. Progress in understanding K(Na) channels has been hampered by the absence of specific tools and methods for rigorous K(Na) identification in native cells. Here, we report the genetic disrupti...

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: Martinez-Espinosa, Pedro L, Wu, Jianping, Yang, Chengtao, Gonzalez-Perez, Vivian, Zhou, Huifang, Liang, Hongwu, Xia, Xiao-Ming, Lingle, Christopher J
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2015
Matèries:
Biophysics and Structural Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641468/
https://ncbi.nlm.nih.gov/pubmed/26559620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.10013
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