Knockout of Slo2.2 enhances itch, abolishes K(Na) current, and increases action potential firing frequency in DRG neurons

Two mammalian genes, Kcnt1 and Kcnt2, encode pore-forming subunits of Na(+)-dependent K(+) (K(Na)) channels. Progress in understanding K(Na) channels has been hampered by the absence of specific tools and methods for rigorous K(Na) identification in native cells. Here, we report the genetic disrupti...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:eLife
Main Authors: Martinez-Espinosa, Pedro L, Wu, Jianping, Yang, Chengtao, Gonzalez-Perez, Vivian, Zhou, Huifang, Liang, Hongwu, Xia, Xiao-Ming, Lingle, Christopher J
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2015
Assuntos:
Biophysics and Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641468/
https://ncbi.nlm.nih.gov/pubmed/26559620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.10013
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados