Aminomethyl Spectinomycins as Novel Therapeutics for Drug Resistant Respiratory Tract and Sexually Transmitted Bacterial Infections

The antibiotic spectinomycin is a potent inhibitor of bacterial protein synthesis with a unique mechanism of action and an excellent safety index, but it lacks antibacterial activity against most clinically important pathogens. A novel series of N-benzyl substituted 3'-(R)- 3'-aminomethyl-...

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Veröffentlicht in:Sci Transl Med
Hauptverfasser: Bruhn, David F., Waidyarachchi, Samanthi L., Madhura, Dora B., Shcherbakov, Dimitri, Zheng, Zhong, Liu, Jiuyu, Abdelrahman, Yasser M., Singh, Aman P., Duscha, Stefan, Rathi, Chetan, Lee, Robin B., Belland, Robert J., Meibohm, Bernd, Rosch, Jason W., Böttger, Erik C., Lee, Richard E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641453/
https://ncbi.nlm.nih.gov/pubmed/25995221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3010572
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