Diacerein retards cell growth of chondrosarcoma cells at the G2/M cell cycle checkpoint via cyclin B1/CDK1 and CDK2 downregulation

BACKGROUND: Chondrosarcoma is characterized for its lack of response to conventional cytotoxic chemotherapy, propensity for developing lung metastases, and low rates of survival. Research within the field of development and expansion of new treatment options for unresectable or metastatic diseases i...

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Publicado en:BMC Cancer
Autores principales: Lohberger, Birgit, Leithner, Andreas, Stuendl, Nicole, Kaltenegger, Heike, Kullich, Werner, Steinecker-Frohnwieser, Bibiane
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2015
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641423/
https://ncbi.nlm.nih.gov/pubmed/26555773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1915-4
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