Somatic loss of function mutations in neurofibromin 1 and MYC associated factor X genes identified by exome-wide sequencing in a wild-type GIST case

BACKGROUND: Approximately 10–15 % of gastrointestinal stromal tumors (GISTs) lack gain of function mutations in the KIT and platelet-derived growth factor receptor alpha (PDGFRA) genes. An alternate mechanism of oncogenesis through loss of function of the succinate-dehydrogenase (SDH) enzyme complex...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Belinsky, Martin G., Rink, Lori, Cai, Kathy Q., Capuzzi, Stephen J., Hoang, Yen, Chien, Jeremy, Godwin, Andrew K., von Mehren, Margaret
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641358/
https://ncbi.nlm.nih.gov/pubmed/26555092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1872-y
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