Succinate dehydrogenase deficiency in a PDGFRA mutated GIST

BACKGROUND: Most gastrointestinal stromal tumors (GISTs) harbor mutually exclusive gain of function mutations in the receptor tyrosine kinase (RTK) KIT (70–80%) or in the related receptor PDGFRA (~10%). These GISTs generally respond well to therapy with the RTK inhibitor imatinib mesylate (IM), alth...

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Bibliografiske detaljer
Udgivet i:BMC Cancer
Main Authors: Belinsky, Martin G., Cai, Kathy Q., Zhou, Yan, Luo, Biao, Pei, Jianming, Rink, Lori, von Mehren, Margaret
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5541693/
https://ncbi.nlm.nih.gov/pubmed/28768491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3499-7
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