Delayed hypertrophic differentiation of epiphyseal chondrocytes contributes to failed secondary ossification in mucopolysaccharidosis VII dogs

Mucopolysaccharidosis (MPS) VII is a lysosomal storage disorder characterized by deficient β-glucuronidase activity, which leads to the accumulation of incompletely degraded glycosaminoglycans (GAGs). MPS VII patients present with severe skeletal abnormalities, which are particularly prevalent in th...

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Detalhes bibliográficos
Publicado no:Mol Genet Metab
Main Authors: Peck, Sun H., O'Donnell, Philip J.M., Kang, Jennifer L., Malhotra, Neil R., Dodge, George R., Pacifici, Maurizio, Shore, Eileen M., Haskins, Mark E., Smith, Lachlan J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641049/
https://ncbi.nlm.nih.gov/pubmed/26422116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2015.09.008
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