Cardiomyocyte-Specific Overexpression of the Ubiquitin Ligase Wwp1 Contributes to Reduction in Connexin 43 and Arrhythmogenesis

Gap junctions (GJ) are intercellular channels composed of connexin subunits that play a critical role in a diverse number of cellular processes in all tissue types. In the heart, GJs mediate electrical coupling between cardiomyocytes and display mislocalization and/or downregulation in cardiac disea...

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Publicado en:J Mol Cell Cardiol
Autores principales: Basheer, Wassim A., Harris, Brett S., Mentrup, Heather L., Abreha, Measho, Thames, Elizabeth L., Lea, Jessica B., Swing, Deborah A., Copeland, Neal G., Jenkins, Nancy A., Price, Robert L., Matesic, Lydia E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641030/
https://ncbi.nlm.nih.gov/pubmed/26386426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2015.09.004
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