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Lessons from hot spot analysis for fragment-based drug discovery
Analysis of binding energy hot spots at protein surfaces can provide crucial insights into the prospects for successful application of fragment-based drug discovery (FBDD), and whether a fragment hit can be advanced into a high affinity, druglike ligand. The key factor is the strength of the top ran...
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| Publicado no: | Trends Pharmacol Sci |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4640985/ https://ncbi.nlm.nih.gov/pubmed/26538314 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tips.2015.08.003 |
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