Langerhans Cells Facilitate UVB-induced Epidermal Carcinogenesis

Ultraviolet B (UVB) light is considered the major environmental inducer of human keratinocyte DNA mutations, including within the tumor-suppressor gene p53, and chronic exposure is associated with cutaneous squamous cell carcinoma (SCC) formation. Langerhans cells (LC) comprise a dendritic network w...

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Publicado en:J Invest Dermatol
Autores principales: Lewis, Julia M., Bürgler, Christina D., Freudzon, Marianna, Golubets, Kseniya, Gibson, Juliet F., Filler, Renata B., Girardi, Michael
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640962/
https://ncbi.nlm.nih.gov/pubmed/26053049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2015.207
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