Langerhans Cells Facilitate Epithelial DNA Damage and Squamous Cell Carcinoma

Polyaromatic hydrocarbons (PAHs) are prevalent, potent carcinogens, and 7,12-dimethylbenz[a]anthracene (DMBA) is a model PAH widely used to study tumorigenesis. Mice lacking Langerhans cells (LCs), a signatory epidermal dendritic cell (DC), are protected from cutaneous chemical carcinogenesis, indep...

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Detalhes bibliográficos
Main Authors: Modi, Badri G., Neustadter, Jason, Binda, Elisa, Lewis, Julia, Filler, Renata B., Roberts, Scott J., Kwong, Bernice Y., Reddy, Swapna, Overton, John D., Galan, Anjela, Tigelaar, Robert, Cai, Lining, Fu, Peter, Shlomchik, Mark, Kaplan, Daniel H., Hayday, Adrian, Girardi, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753811/
https://ncbi.nlm.nih.gov/pubmed/22223807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1211600
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