Langerhans Cells Facilitate Epithelial DNA Damage and Squamous Cell Carcinoma

Polyaromatic hydrocarbons (PAHs) are prevalent, potent carcinogens, and 7,12-dimethylbenz[a]anthracene (DMBA) is a model PAH widely used to study tumorigenesis. Mice lacking Langerhans cells (LCs), a signatory epidermal dendritic cell (DC), are protected from cutaneous chemical carcinogenesis, indep...

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Bibliographic Details
Main Authors: Modi, Badri G., Neustadter, Jason, Binda, Elisa, Lewis, Julia, Filler, Renata B., Roberts, Scott J., Kwong, Bernice Y., Reddy, Swapna, Overton, John D., Galan, Anjela, Tigelaar, Robert, Cai, Lining, Fu, Peter, Shlomchik, Mark, Kaplan, Daniel H., Hayday, Adrian, Girardi, Michael
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753811/
https://ncbi.nlm.nih.gov/pubmed/22223807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1211600
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