Rapid Antidepressant Actions of Scopolamine: Role of Medial Prefrontal Cortex and M1-subtype Muscarinic Acetylcholine Receptors

Clinical studies demonstrate that scopolamine, a nonselective muscarinic acetycholine receptor (mAchR) antagonist, produces rapid therapeutic effects in depressed patients, and preclinical studies report that the actions of scopolamine require glutamate receptor activation and the mechanistic target...

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Publicado en:Neurobiol Dis
Autores principales: Navarria, Andrea, Wohleb, Eric S., Voleti, Bhavya, Ota, Kristie T., Dutheil, Sophie, Lepack, Ashley E., Dwyer, Jason M., Fuchikami, Manabu, Becker, Astrid, Drago, Filippo, Duman, Ronald S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640941/
https://ncbi.nlm.nih.gov/pubmed/26102021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2015.06.012
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