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Targeted binding of nucleocapsid protein transforms the folding landscape of HIV-1 TAR RNA

Retroviral nucleocapsid (NC) proteins are nucleic acid chaperones that play a key role in the viral life cycle. During reverse transcription, HIV-1 NC facilitates the rearrangement of nucleic acid secondary structure, allowing the transactivation response (TAR) RNA hairpin to be transiently destabil...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: McCauley, Micah J., Rouzina, Ioulia, Manthei, Kelly A., Gorelick, Robert J., Musier-Forsyth, Karin, Williams, Mark C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640786/
https://ncbi.nlm.nih.gov/pubmed/26483503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1510100112
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