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Aromatic residue mutations reveal direct correlation between HIV-1 nucleocapsid protein’s nucleic acid chaperone activity and retroviral replication

The human immunodeficiency virus type 1 (HIV-1) nucleocapsid (NC) protein plays an essential role in several stages of HIV-1 replication. One important function of HIV-1 NC is to act as a nucleic acid chaperone, in which the protein facilitates nucleic acid rearrangements important for reverse trans...

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Detalhes bibliográficos
Main Authors: Wu, Hao, Mitra, Mithun, McCauley, Micah J., Thomas, James A., Rouzina, Ioulia, Musier-Forsyth, Karin, Williams, Mark C., Gorelick, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3745225/
https://ncbi.nlm.nih.gov/pubmed/22814429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virusres.2012.07.008
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