Digoxin derivatives with selectivity for the α2β3 isoform of Na,K-ATPase potently reduce intraocular pressure

The ciliary epithelium in the eye consists of pigmented epithelial cells that express the α1β1 isoform of Na,K-ATPase and nonpigmented epithelial cells that express mainly the α2β3 isoform. In principle, a Na,K-ATPase inhibitor with selectivity for α2β3 that penetrates the cornea could effectively r...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Katz, Adriana, Tal, Daniel M., Heller, Dan, Habeck, Michael, Ben Zeev, Efrat, Rabah, Bilal, Bar Kana, Yaniv, Marcovich, Arie L., Karlish, Steven J. D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640782/
https://ncbi.nlm.nih.gov/pubmed/26483500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1514569112
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