Digoxin Derivatives with Enhanced Selectivity for the α2 Isoform of Na,K-ATPase: EFFECTS ON INTRAOCULAR PRESSURE IN RABBITS

In the ciliary epithelium of the eye, the pigmented cells express the α1β1 isoform of Na,K-ATPase, whereas the non-pigmented cells express mainly the α2β3 isoform of Na,K-ATPase. In principle, a Na,K-ATPase inhibitor with selectivity for α2 could effectively reduce intraocular pressure with only min...

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Detalhes bibliográficos
Main Authors: Katz, Adriana, Tal, Daniel M., Heller, Dan, Haviv, Haim, Rabah, Bilal, Barkana, Yaniv, Marcovich, Arie L., Karlish, Steven J. D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Membrane Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110318/
https://ncbi.nlm.nih.gov/pubmed/24917667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.557629
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