Stabilization of the α2 Isoform of Na,K-ATPase by Mutations in a Phospholipid Binding Pocket

The α2 isoform of Na,K-ATPase plays a crucial role in Ca(2+) handling, muscle contraction, and inotropic effects of cardiac glycosides. Thus, structural, functional, and pharmacological comparisons of α1, α2, and α3 are of great interest. In Pichia pastoris membranes expressing human α1β1, α2β1, and...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Kapri-Pardes, Einat, Katz, Adriana, Haviv, Haim, Mahmmoud, Yasser, Ilan, Micha, Khalfin-Penigel, Irena, Carmeli, Shmuel, Yarden, Oded, Karlish, Steven J. D.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2011
Aiheet:
Membrane Biology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234826/
https://ncbi.nlm.nih.gov/pubmed/22027833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.293852
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