Mutational Profiling Can Establish Clonal or Independent Origin in Synchronous Bilateral Breast and Other Tumors

BACKGROUND: Synchronous tumors can be independent primary tumors or a primary-metastatic (clonal) pair, which may have clinical implications. Mutational profiling of tumor DNA is increasingly common in the clinic. We investigated whether mutational profiling can distinguish independent from clonal t...

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Udgivet i:PLoS One
Main Authors: Bao, Lei, Messer, Karen, Schwab, Richard, Harismendy, Olivier, Pu, Minya, Crain, Brian, Yost, Shawn, Frazer, Kelly A., Rana, Brinda, Hasteh, Farnaz, Wallace, Anne, Parker, Barbara A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640562/
https://ncbi.nlm.nih.gov/pubmed/26554380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142487
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