Sustained functional improvement by hepatocyte growth factor-like small molecule BB3 after focal cerebral ischemia in rats and mice

Hepatocyte growth factor (HGF), efficacious in preclinical models of acute central nervous system injury, is burdened by administration of full-length proteins. A multiinstitutional consortium investigated the efficacy of BB3, a small molecule with HGF-like activity that crosses the blood–brain barr...

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Dettagli Bibliografici
Pubblicato in:J Cereb Blood Flow Metab
Autori principali: Chaparro, Rafael E, Izutsu, Miwa, Sasaki, Toshihiro, Sheng, Huaxin, Zheng, Yi, Sadeghian, Homa, Qin, Tao, von Bornstadt, Daniel, Herisson, Fanny, Duan, Bin, Li, Jing-Song, Jiang, Kai, Pearlstein, Molly, Pearlstein, Robert D, Smith, David E, Goldberg, Itzhak D, Ayata, Cenk, Warner, David S
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640251/
https://ncbi.nlm.nih.gov/pubmed/25712497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2015.23
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