Sustained functional improvement by hepatocyte growth factor-like small molecule BB3 after focal cerebral ischemia in rats and mice

Hepatocyte growth factor (HGF), efficacious in preclinical models of acute central nervous system injury, is burdened by administration of full-length proteins. A multiinstitutional consortium investigated the efficacy of BB3, a small molecule with HGF-like activity that crosses the blood–brain barr...

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Vydáno v:J Cereb Blood Flow Metab
Hlavní autoři: Chaparro, Rafael E, Izutsu, Miwa, Sasaki, Toshihiro, Sheng, Huaxin, Zheng, Yi, Sadeghian, Homa, Qin, Tao, von Bornstadt, Daniel, Herisson, Fanny, Duan, Bin, Li, Jing-Song, Jiang, Kai, Pearlstein, Molly, Pearlstein, Robert D, Smith, David E, Goldberg, Itzhak D, Ayata, Cenk, Warner, David S
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640251/
https://ncbi.nlm.nih.gov/pubmed/25712497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2015.23
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