Development of 1-N-(11)C-Methyl-l- and -d-Tryptophan for pharmacokinetic imaging of the immune checkpoint inhibitor 1-Methyl-Tryptophan

1-Methyl-tryptophan (1MTrp) is known as a specific inhibitor targeting the immune- checkpoint protein indoleamine-2,3-dioxygenase, in two stereoisomers of levorotary (l) and dextrorotary (d). A long-standing debate exists in immunology and oncology: which stereoisomer has the potential of antitumor...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Xie, Lin, Maeda, Jun, Kumata, Katsushi, Yui, Joji, Zhang, Yiding, Hatori, Akiko, Nengaki, Nobuki, Wakizaka, Hidekatsu, Fujinaga, Masayuki, Yamasaki, Tomoteru, Shimoda, Yoko, Higuchi, Makoto, Suhara, Tetsuya, Wang, Feng, Zhang, Ming-Rong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4639751/
https://ncbi.nlm.nih.gov/pubmed/26552594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16417
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