Molecular Consequences of Proprotein Convertase 1/3 (PC1/3) Inhibition in Macrophages for Application to Cancer Immunotherapy: A Proteomic Study

Macrophages provide the first line of host immune defense. Their activation triggers the secretion of pro-inflammatory cytokines and chemokines recruiting other immune cells. In cancer, macrophages present an M2 anti-inflammatory phenotype promoting tumor growth. In this way, strategies need to be d...

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Veröffentlicht in:Mol Cell Proteomics
Hauptverfasser: Duhamel, Marie, Rodet, Franck, Delhem, Nadira, Vanden Abeele, Fabien, Kobeissy, Firas, Nataf, Serge, Pays, Laurent, Desjardins, Roxanne, Gagnon, Hugo, Wisztorski, Maxence, Fournier, Isabelle, Day, Robert, Salzet, Michel
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Biochemistry and Molecular Biology 2015
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4638031/
https://ncbi.nlm.nih.gov/pubmed/26330543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M115.052480
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