LKB1 Regulates Cerebellar Development by Controlling Sonic Hedgehog-mediated Granule Cell Precursor Proliferation and Granule Cell Migration

The Liver Kinase B1 (LKB1) gene plays crucial roles in cell differentiation, proliferation and the establishment of cell polarity. We created LKB1 conditional knockout mice (LKB1(Atoh1) CKO) to investigate the function of LKB1 in cerebellar development. The LKB1(Atoh1) CKO mice displayed motor dysfu...

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Vydáno v:Sci Rep
Hlavní autoři: Men, Yuqin, Zhang, Aizhen, Li, Haixiang, Jin, Yecheng, Sun, Xiaoyang, Li, Huashun, Gao, Jiangang
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4637891/
https://ncbi.nlm.nih.gov/pubmed/26549569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16232
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