The MUTYH base excision repair gene protects against inflammation-associated colorectal carcinogenesis

MUTYH DNA glycosylase removes mismatched adenine opposite 7, 8-dihydro-8-oxoguanine (8-oxoG), which is the major mutagenic lesion induced by oxidative stress. Biallelic mutations in MUTYH are associated with MUTYH-Associated polyposis (MAP) and increased risk in colorectal cancer (CRC). We investiga...

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Udgivet i:Oncotarget
Main Authors: Grasso, Francesca, Di Meo, Serena, De Luca, Gabriele, Pasquini, Luca, Rossi, Stefania, Boirivant, Monica, Biffoni, Mauro, Bignami, Margherita, Di Carlo, Emma
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4637313/
https://ncbi.nlm.nih.gov/pubmed/26109431
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