Curcumin analog WZ35 induced cell death via ROS-dependent ER stress and G2/M cell cycle arrest in human prostate cancer cells

BACKGROUND: Prostate cancer is the most commonly diagnosed malignancy among men. The Discovery of new agents for the treatment of prostate cancer is urgently needed. Compound WZ35, a novel analog of the natural product curcumin, exhibited good anti-prostate cancer activity, with an IC(50) of 2.2 μM...

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Vydáno v:BMC Cancer
Hlavní autoři: Zhang, Xiuhua, Chen, Minxiao, Zou, Peng, Kanchana, Karvannan, Weng, Qiaoyou, Chen, Wenbo, Zhong, Peng, Ji, Jiansong, Zhou, Huiping, He, Langchong, Liang, Guang
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636884/
https://ncbi.nlm.nih.gov/pubmed/26546056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1851-3
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