Merkel Cell Polyomavirus Small T Antigen Induces Cancer and Embryonic Merkel Cell Proliferation in a Transgenic Mouse Model

Merkel cell polyomavirus (MCV) causes the majority of human Merkel cell carcinomas (MCC) and encodes a small T (sT) antigen that transforms immortalized rodent fibroblasts in vitro. To develop a mouse model for MCV sT-induced carcinogenesis, we generated transgenic mice with a flox-stop-flox MCV sT...

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Udgivet i:PLoS One
Main Authors: Shuda, Masahiro, Guastafierro, Anna, Geng, Xuehui, Shuda, Yoko, Ostrowski, Stephen M., Lukianov, Stefan, Jenkins, Frank J., Honda, Kord, Maricich, Stephen M., Moore, Patrick S., Chang, Yuan
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636375/
https://ncbi.nlm.nih.gov/pubmed/26544690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142329
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