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Novel thiourea-based sirtuin inhibitory warheads
N(ε)-Thiocarbamoyl-lysine was recently demonstrated by our laboratory to be a potent catalytic mechanism-based SIRT1/2/3 inhibitory warhead, in the current study, among the prepared analogs of N(ε)-thiocarbamoyl-lysine with its terminal NH(2) mono-substituted with alkyl and aryl groups, we found tha...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4636340/ https://ncbi.nlm.nih.gov/pubmed/26081291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.05.058 |
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